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Table 1:

Brain vascular malformations in children with HHT

∼Ten percent of patients with HHT have brain VMs (up to 20% of those with ENG variants)
Risk of hemorrhagic stroke or SAH in children with HHT is 60 times the risk in children without HHT
In cohorts of children with HHT, 3%–5% have intracerebral hemorrhage
Rupture risk of brain AVMs in children with HHT is ∼0.7% per lesion per year (5.5 hemorrhages per 1000 child-years)
Many brain VMs in children with HHT are asymptomatic until rupture