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Differences between local-AIF and global-AIF DSC (ΔqCBF = local-AIF qCBF – global-AIF qCBF) in the 3 territories of interest, with all collateral scores dichotomized into good and poor^{^a}
ΔqCBF Dichotomized by Collateral ScoreMean Difference (mL/100 g/min) [Wilcoxon signed rank statistic, P value]
  Core Infarct Tissue-at-Risk Contralateral Hemisphere
All PCS +2.26 [11.0, P = .68]  +14.3 [5.0, P = .07]* –30.06 [16.0, P = .84] 
Good PCS >8 +10.78 [0.0, P = .125] +25.96 [0.0, P = .06]* –89.2 [2.0, P = .19]
Poor PCS <8 –9.08 [1.0, P = .50] –5.07 [1.0, P = .50]  +68.60 [1.0, P = .50]
↵^aThe underestimation of CBF values by using a single global-AIF compared with a voxelwise local-AIF (ΔqCBF) is greater when collateral supply is robust but not significant in a setting of poor collateral supply; this is especially prevalent in tissue-at-risk.
Statistical significance at the P = .10 level is denoted with *.