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Patient characteristics
Age (yr) Sex Initial Histology Initial Radiation (cGy/fractions) Recurrence Interval (days) Subtraction Interval (days) Tumor Recurrence Volume (mL)
Cohort 1 (model cohort) 
    1 42 M AA 5940/33 3150 28 0.41
    2 61 F GBM 4005/15 298 49 2.70
    3 44 F GBM 5940/33 N/A 91 0.62
    4 63 M GBM 6000/30 137 73 8.67
    5 62 F GBM 6000/30 79 63 0.75
    6 75 M GBM 4005/15 418 56 2.33
    7 62 F GBM 6000/30 719 43 16.41
    8 78 F AA 6000/30 2518 98 1.62
    9 55 M GBM 6000/30 280 63 2.42
    10 63 F GBM 6000/30 159 88 3.27
    11 34 F AA 6000/30 253 37 0.86
    12 32 F GBM 6000/30 522 98 0.39
    Median 62 – – 6000/30 298 63 1.97
Cohort 2 (radiosurgery cohort) 
    A 35 M AA 5940/33 2961 98 0.22
    B 53 M GBM 6000/30 347 87 1.02
    C 60 M GBM 6000/30 663 50 8.88
    D 84 M GBM 4005/15 233 92 3.45
    Median 57 – – 6000/30 505 90 2.23
Note:—AA indicates anaplastic astrocytoma.