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TABLE 1: Baseline characteristics of the CT study group
Baseline Characteristics Control Group (n = 29) AD Group (n = 42) P value^*
Sociodemographics and anthropometrics 
 Mean age at observation ± SD (y) 69 ± 9 76 ± 8 .0007
  (range) (51–82) (57–90) 
 Women 19 (65%) 33 (75%) NS
 Mean education ± SD (y) 9.4 ± 4.9 6.0 ± 3.3 .001
  (range) (2–18) (2–17) 
 Mean head size on axial plane ± SD, cm² 136 ± 12 138 ± 12 NS
  (range) (115–164) (117–166) 
Dementia-related variables 
 MMSE score^† 27.0 ± 0.9 21.1 ± 2.3 <.0001
  (range) (23.4–27.4) (18–27) 
 CDR of 0/.5/1/2 or 3 29/0/0/0 0/18/24/0 <.0001
 Mean disease duration ± SD (mo) — 37 ± 20 
  (range) — (9–96) 
 ApoE ε4 allele^‡ 8/56 (14%) 32/82 (39%) .003
 Lacunes 9 (33%) 7 (17%) NS
 Mean leukoaraiosis score ± SD 5.7 ± 5.0 6.9 ± 5.2 NS
  (range) (0–17) (0–16) 
Physical diseases 
 Ischemic heart disease 3 (9%) 6 (14%) NS
 Cancer 3 (9%) 6 (14%) NS
 Hypertension 10 (35%) 18 (41%) NS
 Diabetes mellitus 1 (4%) 2 (5%) NS
* t test for independent samples, or chi-square test.
† In control subjects, computed on the basis of the telephone version of the test (26, 27).
‡ Data available for 28 historical control subjects and 41 patients with AD (12, 16).