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TABLE 7: Comparison of Known-Group Validity (Discrimination of 28 Patients with AD from 28 Control Subjects) with Linear and Volumetric MR-Based Measures of MTL Atrophy in the MR Group
Control Group AD Group Sensitivity (95% CI)^*
Mean Crude Measure ± SD (mm) Mean Crude Measure ± SD (mm) Mean W-score ± SD
Radial width of the temporal horn (mm) 
 Right 3.7 ± 1.1 6.7 ± 2.0 3.0 ± 1.9 76% (56%–89%)
 Left 3.3 ± 1.5 5.8 ± 2.5 1.7 ± 1.6 51% (32%–70%)
 Largest 4.1 ± 1.2 7.2 ± 2.1 2.7 ± 1.7 73% (53%–87%)
Coronal width of the temporal horn (mm) 
 Right 3.0 ± 1.2 5.3 ± 2.3 2.4 ± 2.3 63% (43%–80%)
 Left 3.2 ± 1.1 6.1 ± 2.3 3.4 ± 2.7 74% (54%–88%)
 Largest 3.4 ± 1.2 6.5 ± 2.3 2.7 ± 2.1 69% (49%–84%)
Hippocampal volume (mm³) 
 Right 1951 ± 335 1309 ± 361 1.7 ± 1.2 52% (33%–71%)
 Left 1797 ± 288 1263 ± 344 1.7 ± 1.0 52% (33%–71%)
 Smallest 1774 ± 282 1191 ± 336 2.3 ± 1.2 71% (51%–86%)
Note.—P < .0005 for difference between groups on t test for all measures. W scores are age-standardized values, that is, the number of SD away from the age-specific atrophy value of control subjects (control W scores, 0 ± 1.0). Greater absolute values indicate greater atrophy.
* Values computed by modeling W scores of Patients with AD and control subjects with specificity set at 95%.