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Table 1: Injection protocol
Group Volume (mL) Rate (mL/s) Duration (s) Concentration Catheter Position
1 Constant, 8 mL Variable, 1, 2, 4, 8 mL/s Variable, 1, 2, 4, 8 seconds Constant, 100% Constant, prox ICA
2 Variable, 4, 8, 12, 16 mL Constant, 4 mL/s Variable, 1–4 seconds Constant, 100% Constant, prox ICA
3 Variable, 4, 8, 12, 16 mL Variable, 2, 4, 6, 8 mL/s Constant, 2 seconds Constant, 100% Constant, prox ICA
4 Constant, 8 mL Constant, 4 mL/s Constant, 2 seconds Variable, 25, 50, 75, 100% Constant, prox ICA
5 Constant, 8 mL Constant, 4 mL/s Constant, 2 seconds Constant, 100% Variable, prox, middle, distal ICA
Note:—Prox ICA indicates proximal internal carotid artery.

Group	Volume (mL)	Rate (mL/s)	Duration (s)	Concentration	Catheter Position
1	Constant, 8 mL	Variable, 1, 2, 4, 8 mL/s	Variable, 1, 2, 4, 8 seconds	Constant, 100%	Constant, prox ICA
2	Variable, 4, 8, 12, 16 mL	Constant, 4 mL/s	Variable, 1–4 seconds	Constant, 100%	Constant, prox ICA
3	Variable, 4, 8, 12, 16 mL	Variable, 2, 4, 6, 8 mL/s	Constant, 2 seconds	Constant, 100%	Constant, prox ICA
4	Constant, 8 mL	Constant, 4 mL/s	Constant, 2 seconds	Variable, 25, 50, 75, 100%	Constant, prox ICA
5	Constant, 8 mL	Constant, 4 mL/s	Constant, 2 seconds	Constant, 100%	Variable, prox, middle, distal ICA