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TABLE 4: 
Comparison of Known-Group Validity (Discrimination of 42 Patients with AD from 29 Control Subjects) with Other Linear CT-Based Measures of MTL Lobe Atrophy in CT Group
Control GroupAD GroupSensitivity (95% CI)*
Mean Crude Measure ± SD (mm)Mean Crude Measure ± SD (mm)Mean W-score ± SD
Radial width of the temporal horn
 Right2.9 ± 1.47.8 ± 3.03.6 ± 2.286% (71%–94%)
 Left2.4 ± 1.37.8 ± 3.24.1 ± 2.483% (68%–92%)
 Largest3.2 ± 1.29.1 ± 3.04.7 ± 2.493% (80%–98%)
Transverse width of the temporal horn
 Right1.0 ± 1.13.7 ± 1.92.2 ± 1.762% (46%–76%)
 Left1.2 ± 1.34.3 ± 2.42.3 ± 1.957% (41%–72%)
 Largest1.5 ± 1.34.7 ± 2.32.4 ± 1.964% (48%–78%)
Minimum thickness of the medial temporal lobe
 Right17.4 ± 2.310.9 ± 3.4−2.7 ± 1.474% (58%–86%)
 Left17.0 ± 3.111.6 ± 3.6−1.9 ± 1.257% (41%–72%)
 Smallest16.4 ± 2.810.2 ± 3.3−2.4 ± 1.274% (58%–86%)
  • Note.—P < .001 for difference between groups on t test for all measures. W scores are age-standardized values; that is, the number of SD away from the age-specific atrophy value of control subjects (W scores in control subjects, 0.0 ± 1.0). Greater absolute values indicate greater atrophy.
  • * Values computed by modeling W scores of patients with AD and control subjects with specificity set at 95%.