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TABLE 4: Cox model applied to assess the effect of 3D measured tumor size on survival
Covariate Univariate Analysis Multivariate Analysis
Coefficient (b_i) HR [exp(b_i)] 95% CI P-value Coefficient (b_i) HR [exp(b_i)] 95% CI P-value
Age 0.038 1.039 (1.014–1.064) .002 0.034 1.034 (1.010–1.058) .005
Sex .015 .003
    Female (0.00) (1.00) (0.00) (1.00) 
    Male 0.725 2.070 (1.153–3.715) 0.936 2.551 (1.361–4.781) 
Previous .096 .115
Chemotherapy 
    No (0.00) (1.00) (0.00) (1.00) 
    Yes 0.433 1.542 (0.926–2.566) 0.430 1.537 (0.900–2.626) 
3D Size 0.019 1.019 (1.009–1.029) .000 0.025 1.026 (0.015–1.036) .000
HR = hazard ratio, CI = confidence interval

Covariate	Univariate Analysis				Multivariate Analysis
Covariate	Coefficient (b_i)	HR [exp(b_i)]	95% CI	P-value	Coefficient (b_i)	HR [exp(b_i)]	95% CI	P-value
Age	0.038	1.039	(1.014–1.064)	.002	0.034	1.034	(1.010–1.058)	.005
Sex				.015				.003
Female	(0.00)	(1.00)			(0.00)	(1.00)
Male	0.725	2.070	(1.153–3.715)		0.936	2.551	(1.361–4.781)
Previous				.096				.115
Chemotherapy
No	(0.00)	(1.00)			(0.00)	(1.00)
Yes	0.433	1.542	(0.926–2.566)		0.430	1.537	(0.900–2.626)
3D Size	0.019	1.019	(1.009–1.029)	.000	0.025	1.026	(0.015–1.036)	.000