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Table 4: Coagulation state and blood pressures at toxicity in 150 patients with PRES: 23 with hemorrhage, 127 without hemorrhage
Blood Pressure at Toxicity No. Pts Normal Coagulation Platelets, Coagulation Parameters, and No Medications (No. Pts with PRES) Abnormal Coagulation
Intrinsic Coagulopathy Thrombocytopenia or Abnormal PT, PTT, INR (No. Pts with PRES) Subtherapeutic, on Medications Affecting Platelet Function or Coagulation (No. Pts with PRES) Therapeutic, on Medication Affecting Platelet Function or Coagulation (No. Pts with PRES)
W/O Hem With Hem W/O Hem With Hem W/O Hem With Hem W/O Hem With Hem
Normotensive (MAP ≤ 105) 44 15 3 17 1 3 1 2 2
Mild HTN (MAP, 106–115) 20 8 2 5 1 3 0 0 1
Severe HTN (MAP ≥ 116) 86 45 5 15 6 10 0 4 1
Total 150 68 10 37 8 16 1 6 4
Note:—W/O indicates without; Hem, hemorrhage; PT, prothrombin time; PTT, partial thromboplastin time; INR, international normalized ratio.