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Demographic clinical characteristics and MR imaging findings at baseline and after 15 months
Healthy Subjects Patients
RRMS SPMS PPMS
M/F 4/6 8/12 6/13 12/19
Mean age (years) 42.6 (31–58) 35.9 (25–43) 49.3 (35–58) 50.1 (25–68)
Median EDSS score NA 3.0 (0.0–5.0) 6.0 (4.0–8.0) 6.0 (2.5–7.0)
Median disease duration (years) NA 5 (0–20) 16 (6–34) 10 (2–26)
Baseline lesion volume (mL) 
    On T2-weighted images NA 13.9 (10.6) 21.7 (17.3) 21.0 (16.9)
    On T1-weighted images NA 3.1 (3.6) 8.5 (7.3) 8.2 (6.9)
Lesion volume change (%) 
    On T2-weighted images NA 9.4 3.8 4.9
    On T1-weighted images NA 3.4 11.0 4.3
Baseline NBV (mL) 1602 (80) 1517 (70) 1464 (90) 1473 (70)
Note.—Data in parentheses are the range or standard deviation. NA indicates not applicable.

	Healthy Subjects	Patients
	Healthy Subjects	RRMS	SPMS	PPMS
M/F	4/6	8/12	6/13	12/19
Mean age (years)	42.6 (31–58)	35.9 (25–43)	49.3 (35–58)	50.1 (25–68)
Median EDSS score	NA	3.0 (0.0–5.0)	6.0 (4.0–8.0)	6.0 (2.5–7.0)
Median disease duration (years)	NA	5 (0–20)	16 (6–34)	10 (2–26)
Baseline lesion volume (mL)
On T2-weighted images	NA	13.9 (10.6)	21.7 (17.3)	21.0 (16.9)
On T1-weighted images	NA	3.1 (3.6)	8.5 (7.3)	8.2 (6.9)
Lesion volume change (%)
On T2-weighted images	NA	9.4	3.8	4.9
On T1-weighted images	NA	3.4	11.0	4.3
Baseline NBV (mL)	1602 (80)	1517 (70)	1464 (90)	1473 (70)