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Case Material
Case No. Age*/Sex Primary CNS Neoplasm Or Disease Age at RT (years) RT and Dose Latency Interval (years) Clinical Presentation Location of CM’s Number of CM’s Treatment of CM’s Associated Findings
1 18/F Posterior fossaMedulloblastoma 3 Craniospinal RT54 Gy (T)36 Gy (CS) 15 Incidental Lt temporal lobe/Intraventricular 1 Observation Meningioma Scalp DFS Panhypopitutarism
Rt cerebellum 1 Observation 
2 6/M Posterior fossaEpendymoma 3 Involved field RT50.4 Gy 3 Incidental (Subsequent asymptomatic Hemorrhage) Lt cerebellumRt cerebellumRt temporal lobe 121 SurgeryObservationObservation TH & GH Deficiency
3 34/M Posterior fossaMedulloblastoma 3 Craniospinal RT54 Gy (T) 36 Gy (CS) 31 Incidental Lt frontal lobe 1 Observation Meningioma
4 21/M Supra-sellarGerminoma 13 Craniospinal RT50.4 Gy (T)36 Gy (CS) 8 Incidental (Subsequent asymptomatic hemorrhage) Rt fronto-parietal lobe 1 Surgery -
5 57/F Cushing’s Disease 16 Cobalt RT Unknown dose 41 Incidental Rt frontal lobe 1 Observation Panhypopitutarism
Note.—Age* indicates Age at the time of diagnosis of cavernomas; RT, Radiation therapy; T, Total Dose; CS, Craniospinal Dose; CM’s, cavernous malformations; DFS, Dermatofibrosarcoma; TH, Thyroid hormones; GH, Growth hormone.