TABLE 3:

Clipping data

Study No.	Reference	Study Type	Mean Age	Patient No.	Definition of Morbidity	AOR (%)	AOE (No.)	95% CI (%)	Mortality (%)
1	Charbel et al, 1991 (40)	RS	43	22	Persistent deficits	18.2	4	11.4–22.7	0.0
2	Awad and Little, 1991 (41)	RS	47	10	Requires occasional assistance	10.0	1	3.9–23.3	0.0
			Median
3	Rabinowicz et al 1991 (42)	RS	Not reported	21	Permanent perioperative complications	19.1	4	12.0–28.9	0.0
4	Taylor et al, 1991 (43)	RS	Not reported	21	Moderate disability to vegetative state	0.0	0	0.0–4.5	0.0
5	Chehrazi, 1992 (13)	RS	52	18	GOS moderate deficit to PVS/death	5.6	1	2.2–13.6	0.0
6	Symon, 1992 (12)	RS	Not reported	34	Author report	8.8	3	5.1–14.9	5.9
7	Inagawa et al, 1992 (18)	RS	Not reported	52	Author report	5.8	3	3.3–9.9	Not reported
8	Nakagawa and Hashi, 1994 (20)	RS	55	20	Author report	5.0	1	1.9–12.3	0.0
9	Dickey et al, 1994 (44)	RS	57	44	Author report	4.6	2	2.3–8.8	0.0
			Median
10	Solomon et al, 1994 (21)	RS	Not reported	202	New neurologic deficits	12.4	25	10.3–14.9	6.9
11	Asari and Ohmoto, 1993 (45)	RS	Not reported	69	Worsened after surgery	7.3	5	4.7–11.0	0.0
12	Mizoi et al, 1995 (14)	RS	57	90	Cannot perform normal activities	0.0	0	0.0–1.1	0.0
13	Dix et al, 1995 (46)	RS	Not reported	66	Cannot perform former activities	3.0	2	1.5–5.9	Not reported
14	Deruty et al, 1996 (25)	RS	Not reported	62	Author report	6.5	4	4.0–10.3	Not reported
15	Khanna et al, 1996 (47)	RS	Not reported	172	Inability to work, no self-care	9.9	17	7.8–12.4	Not reported
16	Leber et al, 1998 (35)	RS	Not reported	16	GOS ≤3	6.3	1	2.4–15.2	6.3
17	Lot et al, 1999 (37)	RS	Not reported	25	Moderate to severe deficit, death	4.8	3	6.9–20.0	0.0
18	Orz et al, 2000 (24)	RM	62	310	Dependent life	5.8	18	4.6–7.3	0.3
19	Johnston et al, 2000 (22)	RS	53	68	mRS change ≥2	25.0	17	20.2–30.6	1.5
20	Chyatte and Porterfield, 2001 (27)	RS	55	366	mRS change ≥2	6.0	22	4.9–7.4	3.8
21	Kashiwagi et al, 2000 (23)	RS	73	96	Dependent/dead	8.3	8	5.9–11.6	5.2
22	Raaymakers, 2000 (26)	PM	44	18	mRS change of ≥2	22.2	4	14.1–33.3	0.0
23	Rinne et al, 1996 (48)	CB	49	33	GOS moderate disability/death	12.1	4	7.6–18.9	0.0
24	Yamashita et al, 1997 (49)	CB	Not reported	349	GOS moderate disability/death	23.8	83	21.6–26.1	Not reported
25	Wiebers et al, 2003 (3)	PM	Not reported	995	mRS ≥3	15.2	151	14.1–16.4	1.8
26	Johnston et al, 1999 (36)	RM	52	2358	D/C to nursing home/rehabilitation hospital	18.5	436	17.7–19.3	2.3
27	Johnston et al, 2001 (2)	CB	54	1699	D/C to nursing home/rehabilitation hospital	25.1	426	24.0–26.1	3.5
28	Barker et al, 2003 (50)	RC	64	3498	Death/discharge to other than home	20.4	714	19.7–21.1	2.1
29	Raftopoulos et al, 2003 (7)	PS	49	33	mRS ≥3	3.0	1	1.2–7.6	0.0
30	Wiebers et al, 2003 (3)	PM	52	1917	mRS 3–5 and/or impaired cognition	13.2	254	12.9–14.6	Not reported

Note.—RS indicates retrospective single center; RM, retrospective multicenter; PM, prospective multicenter; CB, community-based; RC, retrospective cohort; AOR, adverse outcome rate; AOE, adverse outcome event; PVS, persistent vegetative state; GOS, Glasgow Outcome Scale; mRS, modified Rankin Scale.