1naresh
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Low-Grade PCNSL High-Grade PCNSL Radiological morphology Moderate and inhomogeneous or absent contrast enhancement frequent Usually strong and homogemeous contrast enhancement Localization of lesions often without contact to subarachnoid space Lesions typically in contact with the subarachnoid space Hyperintensity of T2-weighted images often present Hyperintensity on T2-weighted images possible Location in deep brain structures and spine common Location in deep brain structures and spine possible but infrequent Clinical characteristics Indolent clinical course possible Aggressive clinical course almost invariably seen Delays in diagnosis establishment possible due to paucity of symptoms and variable radiologic appearance Diagnosis establishment usually rapid due to severe symptoms and typical radiological appearance Long survival with absence of complete tumor remission possible Survival without complete remission usually short Long survival after local treatment (surgery, local radiotherapy) possible Survival with local treatment short, whole brain treatment required
Note.—PCNSL indicates primary central nervous system lymphoma.