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Group comparisons of diffusion indices in the pyramidal tract (PYT) between the lowest section of the cerebral peduncle and the uppermost section of the lateral ventricle
Controls RRMS Patients P Values
NA PYT PYT Lesions Controls Versus NA PYT NA PYT Versus PYT Lesions
FA 0.46 ± 0.02 0.41 ± 0.04 0.34 ± 0.05 <.0001 <.0001
D_av 0.75 ± 0.02 0.85 ± 0.08 0.87 ± 0.09 <.0001 .247
λ₁ 1.28 ± 0.03 1.25 ± 0.07 1.21 ± 0.10 .019 .051
λ₂₃ 0.54 ± 0.02 0.65 ± 0.09 0.70 ± 0.10 <.0001 .007
Note:—RRMS indicates relapsing-remitting multiple sclerosis; NA, normal-appearing; FA, fractional anisotropy; D_av, directionally averaged diffusion coefficient (×10^-3 mm²/s); λ₁, axial diffusion coefficient (×10^-3mm²/s); λ₂₃, radial diffusion coefficient (×10^-3 mm²/s). The group mean ± SD for the diffusion indices (Mann-Whitney U test) is reported in the second through fourth columns. A P value of <.01 is considered statistically significant, whereas a value between .01 and 0.05 is considered to represent a trend. The P values indicated that RRMS has abnormal diffusion in the normal-appearing PYT.