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Table 3: Gray-matter volume loss in patients with ALS compared to healthy subjects (P < .001, uncorrected)
Anatomical Location Cluster Size k MNI Coordinates^* (mm) Z-Score
x y z
Right temporal lobe 
    Subgyral 439 42 −13 −23 3.80
    Superior temporal gyrus-uncus 75 33 8 −27 3.24
    Middle temporal gyrus 366 58 5 −26 3.33
    Parahippocampal gyrus 1047 32 −11 −9 3.53
    Middle temporal gyrus 186 61 −5 −14 3.55
Left temporal lobe 
    Middle temporal gyrus 200 −58 3 −21 3.33
    Subgyral 1464 −36 −4 −17 3.84
Right frontal lobe 
    Inferior frontal gyrus 292 43 23 −14 3.31
    Inferior frontal gyrus 197 29 19 −9 3.34
    Extranuclear insula 704 33 −1 22 4.01
    Superior frontal gyrus 81 39 57 32 3.41
Left frontal lobe 
    Inferior frontal gyrus 112 −40 23 −13 3.36
    Insula 147 −31 4 15 3.39
* The coordinates refer to the Montreal Neurological Institute (MNI) space and denote the areas of maximal gray matter volume loss within each cluster.