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Table 2: Whole-brain histogram analysis of the ADC and MTR maps and SIENAX results in the three groups of subjects
CEC (n = 10) CD (n = 8) Healthy Subjects (n = 17)
ADC (× 10⁻³ mm²/s) 
    25th Percentile 0.75 ± 0.02^* 0.69 ± 0.04 0.72 ± 0.02
    50th Percentile 0.88 ± 0.04^* 0.89 ± 0.05^† 0.83 ± 0.03
    75th Percentile 1.07 ± 0.09 1.15 ± 0.15 1.08 ± 0.11
    Kurtosis 3.88 ± 0.46^* 4.53 ± 0.52 4.96 ± 0.77
    Skewness 0.99 ± 0.25^* 1.32 ± 0.36 1.42 ± 0.21
MTR 
    25th Percentile 46.44 ± 2.94 48.55 ± 2.09 48.55 ± 2.16
    50th Percentile 49.79 ± 2.71 51.44 ± 2.45 51.80 ± 2.03
    75th Percentile 52.61 ± 2.60 54.03 ± 2.60 54.86 ± 2.07
    Kurtosis 14.85 ± 4.03 16.91 ± 3.92 16.36 ± 3.86
    Skewness −2.56 ± 0.50 −2.83 ± 0.52 −2.62 ± 0.76
Normalized brain volume (mm³) 1,462,447 ± 39,769 1,486,052 ± 127,408 1,470,909 ± 75,721
Note:—ADC indicates apparent diffusion coefficient; MTR, magnetization transfer ratio; SIENAX, structural image evaluation, using normalization of atrophy, single time-point version; CEC, celiac disease, epilepsy, and cerebral calcifications; CD, celiac disease.
* P < .01 for the difference between patients with CEC and healthy subjects.
† P < .01 for the difference between patients with CD and healthy subjects.