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Table 1: Comparison between the ssT1 and fpT2* methods: theoretical and practical considerations
ssT1 Method fpT2* Method
Theoretical considerations 
    Shape of contrast agent concentration time curve Bi-exponential decay Gamma-variate
    Concentration of intravascular contrast agent Lower Higher
    K^trans for normal brain tissue Zero Negligible or very small, but not zero
    Rate of contrast agent movement from intravascular to extravascular space within a single voxel of tissue Slower Faster
Practical considerations 
    Spatial resolution Higher Lower
    Subjectivity to susceptibility artifact No Yes
    Imaging time Longer (>6 min) Shorter (<1.5 min)
    Postprocessing algorithm complexity Higher Lower

	ssT1 Method	fpT2* Method
Theoretical considerations
Shape of contrast agent concentration time curve	Bi-exponential decay	Gamma-variate
Concentration of intravascular contrast agent	Lower	Higher
K^trans for normal brain tissue	Zero	Negligible or very small, but not zero
Rate of contrast agent movement from intravascular to extravascular space within a single voxel of tissue	Slower	Faster
Practical considerations
Spatial resolution	Higher	Lower
Subjectivity to susceptibility artifact	No	Yes
Imaging time	Longer (>6 min)	Shorter (<1.5 min)
Postprocessing algorithm complexity	Higher	Lower