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Table 1: 
Demographic, clinical, and MR imaging data
Patients with AD(n = 18)Control Subjects(n = 18)P*
Age (y)69.1 (6.8)67.1 (8.9).45
Male, n (%)10 (56)11 (61).74
MMSE19.1 (6.2)29.7 (0.6)<.0001
Adjusted WB volume (ml)1019 (76)1125 (61)<.0001
Adjusted total Hc volume (ml)4.13 (0.70)5.64 (0.51)<.0001
WB MTR (pu)39.79 (0.72)40.51 (0.58).002
Hc mean MTR (pu)36.71 (0.78)37.92 (0.62)<.0001
PWM mean MTR (pu)44.60 (1.20)44.98 (0.71).26
Pons mean MTR (pu)44.49 (1.72)44.37 (1.62).83
WB MTR peak height (%vol/pu)7.29 (0.66)7.60 (0.31).08
WB MTR peak location (pu)42.43 (1.01)42.47 (0.86).92
WB MTR 25th percentile (pu)36.42 (1.15)37.14 (0.62).03
WB MTR median (pu)40.94 (0.79)41.31 (0.53).11
WB MTR 75th percentile (pu)44.58 (0.58)44.75 (0.49).34
  • Note:—MMSE indicates Mini-Mental State Examination; WB, whole brain; Hc, hippocampus; pu, percentage units; vol, volume; MTR, magnetization transfer ratio; PWM, parietal white matter. Values are mean (SD) unless otherwise specified.
  • * Two-sample t test for all comparisons except sex, where Pearson χ2 test was used.