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Table 2: Course of radiologic ND-LCH in the cerebellum, anterior pons, and basal ganglia in 9 patients
Patient Follow-Up
At Diagnosis 3 years 6 years 9 years 12 years
1 
    Cerebellum ++ ++ ++ ++ 
    Basal ganglia − + ++ ++ 
    Anterior pons − − − − 
2 
    Cerebellum ++ ++ ++ ++ 
    Basal ganglia + + ++ ++ 
    Anterior pons − − − − 
3 
    Cerebellum + + + 
    Basal ganglia + + ++ 
    Anterior pons − − − 
4 
    Cerebellum +++^* +++^* +++^* 
    Basal ganglia +^* ++^* ++^* 
    Anterior pons +^* +^* +^* 
5 
    Cerebellum + ++ +++ +++ +++
    Basal ganglia − + + + +
    Anterior pons − − + + +
6 
    Cerebellum +++ +++ +++ +++ 
    Basal ganglia + +++ +++ +++ 
    Anterior pons − − − − 
7 
    Cerebellum + + + 
    Basal ganglia − + + 
    Anterior pons − − − 
8 
    Cerebellum + +++ +++^* +++^* +++^*
    Basal ganglia − + ++^* ++^* ++^*
    Anterior pons − + ++^* ++^* ++^*
9 
    Cerebellum ++ ++ +++ 
    Basal ganglia − − ++ 
    Anterior pons − − − 
Note:—ND indicates neurodegeneration; LCH, Langerhans cell histiocytosis; Cerebellum: +, mild signal alterations limited to the dentate nucleus; ++, moderate signal alterations in dentate nucleus; +++, extensive signal alterations in the dentate nucleus, cerebellar white matter, middle cerebellar peduncles, and dorsal part of the pons. Anterior pons: −, normal; +, subtle signal alterations; ++, prominent signal alterations. Basal ganglia: −, normal; +, mild signal alterations limited to the pallidum; ++, moderate signal alterations limited to the pallidum; +++, extensive alterations involving the pallidum and the putamen.
* Radiologic ND-LCH associated with neurologic symptoms.