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Table 1: 
Lesions demonstrating Rosenthal fibers
CategoryExamples
ReactiveParenchyma surrounding slowly growing, low-grade tumorsHemangioblastoma, craniopharyngioma
Parenchyma surrounding cystsSyringomyelia, pineal cyst
Parenchyma surrounding vascular malformationsArteriovenous malformations, cavernomas
Parenchyma surrounding chronic inflammationMultiple sclerosis
NeoplasticPilocytic astrocytoma, ganglioglioma, pleomorphic xanthoastrocytoma
Genetic/metabolicAlexander disease
  • Note:—This table has been modified from refs. 12 and 18. With permission.