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Results in newborns and premature babies
PT (n = 11)PTT (n = 13)FT (n = 12)P (ANOVA, PT vs PTT vs FT)P (ANOVA, PT vs PTT)
Absolute Units (cm3)Relative to ICV (%)Absolute Units (cm3)Relative to ICV (%)Absolute Units (cm3)Relative to ICV (%)P Absolute UnitsP Relative to ICVP Absolute UnitsP Relative to ICV
ICV269.8 ± 36.5431.7 ± 70.0427.4 ± 53.8F = 31.0P < .001F = 47.6 P < .001
Total brain volume246.5 ± 32.3391 ± 66.1395 ± 49.2F = 30.2 P < .001F = 43.5 P < .001
CGM83.5 ± 22.230.6 ± 5.1179 ± 41.541.0 ± 5.4181.4 ± 29.342.4 ± 4.1F = 33.6 P < .001F = 23.1 P < .001F = 46.6 P < .001F = 23.1 P < .001
UMWM142.4 ± 15.053.1 ± 4.8185.3 ± 30.843.2 ± 5.1183.4 ± 27.443.0 ± 4.4F = 10.1 P < .001F = 16.8 P < .001F = 17.6 P < .001F = 23.7 P < .001
MWM6.1 ± 1.82.2 ± 0.510.7 ± 3.02.5 ± 0.810.72 ± 4.632.5 ± 1.0F = 7.0 P = .003F = 0.4 P > .1F = 18.8 P < .001F = 1.0 P > .1
BG14.2 ± 4.25.4 ± 1.715.7 ± 5.73.7 ± 1.117.14 ± 4.394.0 ± 0.9F = 1.0 P > .1F = 5.8 P = .007F = 0.5 P > .1F = 8.6 P = .008
CSF23.3 ± 9.68.6 ± 3.040.7 ± 21.29.5 ± 4.332.4 ± 11.07.5 ± 2.3F = 3.8 P = .03F = 1.0 P > .1F = 6.2 P = .02F = 0.4 P > .1
  • Note:—Fifteen premature babies had 2 MRIs, one after birth (PT) and one at 40 wks (PTT); 12 newborns had an MRI at 40 wks (FT). ICV indicates intracranial volume; CGM, cortical gray matter; UMWM, ummyelinated white matter; MWM, myelinated white matter; BG, basal ganglia; CSF, cerebrospinal fluid.