Table 2:

Average MD and FA values of ROIs from patients with RNMO and control subjects

ROI	Average MD (×10⁻³ mm² s⁻¹)			Average FA
ROI	RNMO	Controls	P^* (95% CI)	RNMO	Controls	P^* (95% CI)
Medulla oblongata	1.271 ± 0.111	1.111 ± 0.102	<.001	0.266 ± 0.014	0.287 ± 0.026	.005
	(1.212–1.330)	(1.057–1.165)	(0.084 to 0.237)	(0.259–0.274)	(0.275–0.300)	(−0.035 to −0.007)
Cerebral peduncle	1.007 ± 0.111	0.872 ± 0.053	<.001	0.489 ± 0.035	0.535 ± 0.024	<.001
	(0.948–1.066)	(0.843–0.900)	(0.072 to 0.198)	(0.471–0.508)	(0.522–0.548)	(−0.067 to −0.024)
Internal capsule	0.735 ± 0.010	0.718 ± 0.011	<.001	0.661 ± 0.019	0.693 ± 0.022	<.001
	(0.730–0.741)	(0.712–0.723)	(0.010 to 0.065)	(0.651–0.671)	(0.681–0.705)	(−0.047 to −0.017)
Optic radiation	0.876 ± 0.033	0.824 ± 0.031	<.001	0.527 ± 0.039	0.585 ± 0.030	<.001
	(0.859–0.894)	(0.808–0.840)	(−0.076 to −0.029)	(0.506–0.547)	(0.569–0.601)	(−0.083 to −0.033)
Splenium of corpus callosum	0.759 ± 0.034	0.726 ± 0.033	.009	0.815 ± 0.034	0.817 ± 0.033	.846
	(0.741–0.777)	(0.708–0.743)	(0.009 to 0.057)	(0.796–0.833)	(0.799–0834)	(−0.027 to 0.022)
Genu of corpus callosum	0.765 ± 0.049	0.731 ± 0.038	.033	0.832 ± 0.033	0.829 ± 0.020	.741
	(0.739–0.794)	(0.711–0.751)	(0.003 to 0.066)	(0.814–0.849)	(0.818–0.839)	(−0.016 to 0.023)
Putamen	0.729 ± 0.012	0.721 ± 0.011	.068
	(0.722–0.735)	(0.715–0.727)	(−0.001 to 0.016)
Thalamus	0.775 ± 0.022	0.760 ± .025	.066
	(0.763–0.786)	(0.746–0.772)	(−0.001 to 0.032)
Frontal gray matter	0.674 ± 0.042	0.634 ± 0.050	.023
	(0.651–0.696)	(0.608–0.661)	(0.006 to 0.073)
Parietal gray matter	0.807 ± 0.014	0.779 ± 0.016	<.001
	(0.800–0.814)	(0.771–0.788)	(0.017 to 0.038)
Temporal gray matter	0.838 ± 0.020	0.823 ± 0.011	.016
	(0.827–0.849	(0.818–0.829)	(0.003 to 0.026)
Occipital gray matter	0.780 ± 0.012	0.758 ± 0.016	.007
	(0.770–0.790)	(0.746–0.770)	(0.006 to 0.036)

Note:—RNMO indicates relapsing neuromyelitis optica; MD, mean diffusivity; FA, fractional anisotropy; ROI, region of interest. Values are expressed as mean ± SD (95% confidence interval).
* Statistical analysis: Student t test for independent samples; P < .005 is considered significant.