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Table 4: Spearman rank correlation (ρ) values between visual score of LA, brain volumes, MD and FA histogram metrics, and motor and neuropsychologic scores
Variable SPPB Usual Gait Velocity, m/s Single-Leg Stance Time, s MMSE Stroop Test Trail-Making Test Maze Task Digit Verbal Fluency
Fazekas scale −0.18 −0.15 −0.26 −0.19 0.13 0.08 0.11 −0.23 −0.28
Normalized brain volume 0.38 0.02 −0.22 −0.05 −0.09 −0.08 −0.18 0.15 −0.04
Gray matter −0.01 −0.11 −0.11 −0.10 −0.14 0.07 0.17 −0.10 0.06
White matter 0.28 0.26 −0.04 −0.02 0.02 −0.14 −0.29 0.24 −0.05
Whole-brain MD 
    25th percentile −0.21 −0.32 −0.48 −0.28 0.51 0.30 0.32 −0.30 −0.46
(P = .006) (P = .001) (P = .004)
    50th percentile −0.15 −0.20 −0.35 −0.16 0.54 0.31 0.30 −0.31 −0.44
(P < .001) (P = .007)
    Skewness −0.28 0.34 0.16 0.34 −0.23 −0.42 −0.44 0.45 0.13
(P = .008) (P = .006) 
    Kurtosis 0.24 0.25 0.16 0.35 −0.17 −0.37 −0.38 0.40 0.06
Whole-brain FA 
    25th percentile −0.02 −0.00 −0.01 −0.24 −0.11 −0.01 −0.17 −0.08 0.10
    50th percentile 0.04 −0.10 0.09 −0.18 −0.17 −0.06 −0.09 0.01 0.17
    Skewness −0.18 −0.35 −0.21 −0.15 0.26 0.14 0.18 −0.28 −0.41
    Kurtosis −0.22 −0.39 −0.27 −0.21 0.32 0.18 0.21 −0.32 −0.46
(P = .005)
Note:—LA indicates leukoaraiosis; MD, mean diffusivity; FA, fractional anisotropy; SPPB, Short Physical Performance Battery; MSSE, Mini Mental State Examination.