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Table 2:

Fibrinolytic dosing

No.IV tPA dose (mg/kg)IA tPA dose (mg)Total tPA Dose (mg)Total tPA dose (mg/kg)
IV tPA only170.68 ± 0.1452.6 ± 17.30.68 ± 0.14
    Lower dose120.60 ± 0.0445.0 ± 8.970.60 ± 0.04
    Regular dose50.88 ± 0.0370.9 ± 19.50.88 ± 0.03
IA tPA only2714.0 ± 9.6514.0 ± 9.650.19 ± 0.14
IA + IV tPA130.67 ± 0.177.54 ± 3.9169.3 ± 12.50.76 ± 0.17
    Lower dose70.53 ± 0.058.87 ± 4.6764.4 ± 8.740.61 ± 0.04
    Regular dose60.85 ± 0.066.00 ± 2.2874.9 ± 14.50.93 ± 0.08
  • Note:—IV indicates intravenous; IA, intraarterial; tPA, tissue plasminogen activator.

    Doses are shown as means ± SD; 3 patients each received 250,000 U of urokinase IA and IV tPA (not shown).