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Clinical and MR imaging findings in patients with ALS
Patient No.Age (y)SexDuration Before MRI (y)Dementia (HDS-R)Bulbar SymptomsUpper Motor Neuron SymptomsLower Motor Neuron Symptoms, Upper ExtremitiesLower Motor Neuron Symptoms, Lower ExtremitiesAtrophy Frontotemporal Lobes*HI Anterior Temporal White MatterHI Bilateral Precentral White MatterHI Bilateral Corticospinal TractsHI Bilateral Precentral CorticesSmall Infarction or Unidentified Bright Objects
158M1+, 17/30+−++2, T, bilateral+, bilateral−−+−
265M6+, 14/30+−++3, T, bilateral+, bilateral+−−+
371F2+, 9/30+−++2, Fr, bilateral+, bilateral−−−+
Subtotal64.7 ± 6.53.0 ± 2.6100%2.33100%33.3%0%33.3%66.7%
446M1−++++1−−−−−
550F6−++++1−−−+−
654F6−−+++1−−−−−
755F2−++++2, Fr, bilateral−+++−
857M1−++++1−−−−+
957M3−+−−−1−−−−+
1058F1−++++1−++++
1160F1−+++−1−−++−
1262F0−+++−1−++++
1362F2−++++2, Fr, bilateral−−+++
1462M4−++++2, T, bilateral−−−++
1562M6−+++−1−−−−+
1665M7−+++−2, T, bilateral−−−−−
1767M2−−+−+1−+−+−
1869M8−++++1−−−++
1970F2−++++1−+−++
2071M5−++++2, T, bilateral−+−++
2174F1−++++1−+−−+
2274M2−−−++2, Fr, bilateral−−−−+
2374M4−++++1−++++
2474M4−+−++1−+−++
Subtotal63.0 ± 8.33.2 ± 2.30%1.330%42.9%28.6%61.9%66.7%
Total63.2 ± 8.03.2 ± 2.312.5%1.4612.5%41.7%37.5%58.3%66.7%
  • Note:—HI indicates hyperintensity; Fr, frontal dominance; T, temporal dominance; +, present; −, absent.
  • * 3 indicates severe; 2, moderate; 1, mild or absent.