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Table 1:

Metabolite peak-area ratios for Lac/Cr, Lac/NAA, Lac/Cho, NAA/Cr, NAA/Cho, and Cho/Cr

Metabolite RatioControl Group (n = 10)Neonatal Encephalopathy Group (n = 17)P Values
Normal/Mild Outcome (n = 10)Severe/Fatal Outcome (n = 7)Control Versus Normal/Mild OutcomeControl Versus Severe/Fatal OutcomeNormal/Mild Outcome Versus Severe/Fatal Outcome
Lac/Cr0.38 (0.10)0.41 (0.13)0.70 (0.45–2.65).61.04*.06
Lac/NAA0.24 (0.06)0.29 (0.09)0.54 (0.35–2.66).11.02*.03*
Lac/Cho0.15 (0.03)0.19 (0.05)0.32 (0.22–1.26).06.02*.04*
NAA/Cr1.59 (0.19)1.41 (0.28)1.16 (0.14).09<.001*.04*
NAA/Cho0.66 (0.08)0.67 (0.09)0.56 (0.11).73.04*.04*
Cho/Cr2.47 (0.57)2.10 (0.31)2.12 (0.36).09.17.91
  • Note:β€”Lac indicates lactate; NAA, N-acetylaspartate; Cho, choline; Cr, creatine.

  • * Denotes statistically significant differences between the groups. Values are mean (SD) and median (interquartile range) as appropriate.