Table 2:

Magnetization transfer ratio (MTR) and T₁ histogram parameters of lesion and normal-appearing white matter (NAWM) pixel classes and of control white matter (WM)

Pixel class	Type of MS	T₁		MTR
Pixel class	Type of MS	Peak position (ms)	Peak height (10⁻³)	Peak position (%)	Peak height (10⁻³)
Lesion core	PP	1050 ± 173^**^††	1.9 ± 1.1^**^††	26.1 ± 3.8^**^††	7.2 ± 2.1^**^††
	RR	1053 ± 144^**^††	1.8 ± 0.5^**^††	24.5 ± 3.1^**^††	7.2 ± 1.6^**^††
	SP	1020 ± 129^**^††	1.6 ± 0.4^**^††	25.1 ± 2.7^**^††	6.6 ± 0.7^**^††
Lesion rim	PP	833 ± 49^**^††	3.0 ± 0.9^**^††	30.1 ± 1.3^**^††	8.4 ± 1.5^**^††
	RR	851 ± 54^**^††	2.8 ± 0.7^**^††	29.5 ± 2.1^**^††	8.4 ± 1.2^**^††
	SP	868 ± 46^**^††	2.7 ± 0.6^**^††	28.8 ± 1.7^**^††	8.4 ± 1.1^**^††
NAWM Layer 1	PP	777 ± 23	6.2 ± 0.9^**	31.9 ± 0.9^**	12.7 ± 1.5^*
	RR	782 ± 28^†	6.8 ± 1.4^**	31.6 ± 1.1^**^†	13.1 ± 1.3^*
	SP	804 ± 36^†	6.0 ± 1.0^**	31.0 ± 1.4^**^†	12.9 ± 1.2^*
NAWM Layer 2	PP	764 ± 17	7.0 ± 0.8^*	32.5 ± 1.0^*	13.0 ± 1.4^*
	RR	770 ± 21	7.2 ± 1.0^*	32.2 ± 1.0^*	13.8 ± 1.5^*^†
	SP	797 ± 34^†	6.3 ± 1.0^*	31.5 ± 1.3^*	13.3 ± 1.1^*
NAWM Layer 3	PP	757 ± 18	7.1 ± 0.9^*	32.4 ± 0.7	12.9 ± 1.4^*
	RR	768 ± 30	7.0 ± 0.8^*	32.5 ± 0.9	13.9 ± 1.2^*^†
	SP	791 ± 38^†	6.2 ± 1.0^*	31.7 ± 1.2	13.2 ± 1.1^*
NAWM Layer 4	PP	744 ± 49	6.8 ± 0.8^*	32.6 ± 0.6	12.9 ± 1.3^*
	RR	770 ± 26	6.9 ± 0.8^*	32.4 ± 0.9	13.9 ± 1.3^*^†
	SP	796 ± 43^†	6.1 ± 1.0^*	31.9 ± 1.0	13.2 ± 1.1^*
Distant NAWM	PP	756 ± 17	6.1 ± 1.0	32.6 ± 0.6	11.8 ± 1.6
	RR	764 ± 25	6.0 ± 0.9^†	32.8 ± 0.8	12.8 ± 1.1
	SP	793 ± 37^†	5.0 ± 1.2^††	32.0 ± 1.0	11.9 ± 1.0
Control WM		747 ± 22	7.0 ± 0.7	32.8 ± 1.0	12.6 ± 1.1

Note:—Values are observed means and SDs. Symbols indicate statistically significant differences:
* P < .05,
** P < .001 versus distant NAWM,
† P < .05,
†† P < .001 versus control WM. Details of the applied linear mixed model are given in the text. MS indicates multiple sclerosis; PP, primary progressive; RR, relapsing-remitting; SP, secondary progressive.