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Table 1: Subject group characteristics
PPMS RRMS SPMS Combined MS group Controls
Subjects (M/F) 11 (7/4) 34 (10/24) 18 (7/11) 63 (24/39) 22 (12/10)
Age (y) 58.4 ± 6.0 39.4 ± 7.1 44.3 ± 10.5 44.1 ± 10.6 30.7 ± 7.6
Disease duration (y) 11.8 ± 5.1 9.1 ± 5.3 15.8 ± 9.0 11.6 ± 7.2 
Median EDSS (range) 4.5 (3.0–6.5) 2.0 (1.5–4.0) 6.0 (2.5–8.0) 3.0 (1.5–8.0) 
MSFC 0.15 ± 0.53 0.57 ± 0.30 −0.27 ± 0.72 0.26 ± 0.61 
NBV (L) 1.41 ± 0.04 1.48 ± 0.06 1.41 ± 0.05 1.45 ± 0.06 1.52 ± 0.04
Median lesion load, mL (range) 6.8 (0.2–27.8) 5.6 (0.3–41.2) 10.8 (2.5–54.7) 6.8 (0.2–54.7) 
Note:—MS indicates multiple sclerosis, specified by type as primary progressive (PPMS), relapsing-remitting (RRMS), and secondary progressive (SPMS); EDSS, Expanded Disability Status Scale; MSFC, Multiple Sclerosis Functional Composite; NBV, normalized brain volume.