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Discrete lesions identified on diffusion-weighted MR imaging (DWI) and high-resolution DWI (DWI-HR)
DWI DWI-HR P Value
Signal-to-noise ratio, mean (range) 29.7 (23.9–37) 35.6 (27.7–43.2) <.01
Contrast-to-noise ratio, mean (range) 10.7 (8–17) 14.8 (12.6–20.6) <.01
Total no. of lesions 129 253 <.001
Average no. of lesions 3.07 6.04 <.001
No. of unique lesions 7 123 <.001
Total lesion volume (mm³) 7040 ± 2010 7052 ± 1950 .95
Average volume per lesion (mm³) 3600 ± 1300 2800 ± 1200 <.001
Average volume per lesion of unique lesions (mm³) 134.41 ± 88.23 70.50 ± 16.90 .65
No. of patients with a single lesions, n (%) 16 (37%) 12 (28%) n/a
Number of patients with greater than 5 lesions, n (%) 8 (19%) 19 (42%) n/a
Note:—DWI-HR was acquired following a tetrahedronal encoding scheme with the following gradient directions: (0, 1, 1), (−1, 0, 1), (0, 1, 1), (1, 1, 0), (0, 1, −1), (−1, 1, 0). 100% gradient strength was applied simultaneously along 2 axes affecting a factor of 2 gain in ‖b‖, and allowing for a shorter echo time.