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Table 3: Spectroscopy findings obtained from PWM, FWM, and thalamus in patients and control subjects (mean ± SD)
Patients (before Therapy) Control (Newborn, 5–7 days) P Value Patients (after therapy) Control (after 8 weeks) P Value
FWM 0.88 ± 0.27 1.06 ± 0.16 N.S. 1.28 ± 0.35 1.43 ± 0.17 NS
NAA/Cr
FWM 2.12 ± 0.77 2.02 ± 0.46 N.S. 1.50 ± 0.33 1.73 ± 0.20 NS
Cho/Cr
Thalamus 1.09 ± 0.24 1.29 ± 0.13 <0.05 1.45 ± 0.17 1.38 ± 0.21 NS
NAA/Cr
Thalamus 1.78 ± 0.35 1.70 ± 0.18 NS 1.44 ± 0.15 1.37 ± 0.26 NS
Cho/Cr
PWM 1.04 ± 0.23 1.38 ± 0.17 <0.05 1.39 ± 0.25 1.52 ± 0.29 NS
NAA/Cr
PWM 1.91 ± 0.39 1.89 ± 0.42 NS 1.33 ± 0.25 1.57 ± 0.21 NS
Cho/Cr
Note:—FWM indicates frontal while matter; NAA, N-acetylaspartate; Cr, creatine; Cho, choline; PWM, parietal white matter; NS, nonsignificant (P > .05).

	Patients (before Therapy)	Control (Newborn, 5–7 days)	P Value	Patients (after therapy)	Control (after 8 weeks)	P Value
FWM	0.88 ± 0.27	1.06 ± 0.16	N.S.	1.28 ± 0.35	1.43 ± 0.17	NS
NAA/Cr	0.88 ± 0.27	1.06 ± 0.16	N.S.	1.28 ± 0.35	1.43 ± 0.17	NS
FWM	2.12 ± 0.77	2.02 ± 0.46	N.S.	1.50 ± 0.33	1.73 ± 0.20	NS
Cho/Cr	2.12 ± 0.77	2.02 ± 0.46	N.S.	1.50 ± 0.33	1.73 ± 0.20	NS
Thalamus	1.09 ± 0.24	1.29 ± 0.13	<0.05	1.45 ± 0.17	1.38 ± 0.21	NS
NAA/Cr	1.09 ± 0.24	1.29 ± 0.13	<0.05	1.45 ± 0.17	1.38 ± 0.21	NS
Thalamus	1.78 ± 0.35	1.70 ± 0.18	NS	1.44 ± 0.15	1.37 ± 0.26	NS
Cho/Cr	1.78 ± 0.35	1.70 ± 0.18	NS	1.44 ± 0.15	1.37 ± 0.26	NS
PWM	1.04 ± 0.23	1.38 ± 0.17	<0.05	1.39 ± 0.25	1.52 ± 0.29	NS
NAA/Cr	1.04 ± 0.23	1.38 ± 0.17	<0.05	1.39 ± 0.25	1.52 ± 0.29	NS
PWM	1.91 ± 0.39	1.89 ± 0.42	NS	1.33 ± 0.25	1.57 ± 0.21	NS
Cho/Cr	1.91 ± 0.39	1.89 ± 0.42	NS	1.33 ± 0.25	1.57 ± 0.21	NS