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Characteristics of subjects*

CharacteristicsOverallDonepezilPlacebo
No.1367
Age (yr)68 (6.9)64.7 (6.0)70.9 (6.7)
Education (yr)16.2 (2.3)17.5 (2.1)15.1 (2.0)
ScoresPrePostPrePost
MMSE28.3 (1.7)28.3 (1.9)29.8 (0.4)28.3 (1.7)28 (2.5)
ADAS-Cog§25.0 (5.4)23.3 (3.5)20.6 (5.5)26.5 (6.5)22.8 (6.5)
NYU Delayed Recall6.7 (3.0)7.33 (1.0)8.0 (2.8)6.14 (4.1)6.7 (2.8)
fMRI task (% correct)79.1 (11.8)77.1 (16.4)78.0 (10)79.1 (8.9)86.3 (13.5)
  • Note:—NYU indicates New York University; MMSE, Mini-Mental State Examination; ADAS-Cog, Alzheimer Disease Assessment Scale-Cognitive Subscale.

  • * All table cells list the mean and standard deviation.

  • Education refers to period of formal schooling as reported by the patient.

  • Trend (P = .09) for Treatment Group × Time interaction.

  • § Significant (P < .05) main effect of time across both treatment groups.