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Table 4: Longitudinal structural MRI studies on at-risk subjects
MRI Study N Decline Baseline Clinical Characteristics^* FU ROI Mag
Age (yr) M MMSE Ed
Galton et al, 2005²⁴ 29/11 ND to AD 63.7 (9.9) 48.2 27.4 (2.4) NA 24.2 HIP NA
Convit et al, 2000²⁵ 46/14 NL and MCI to AD^† 74.0 (7.0) 47.8 27.8 (2.4) 14.8 (3.0) 38.4 MTL 1.5
Devanand et al, 2007²⁶ 114/31 MCI to AD 66.8 (9.8) 43.9 27.5 (2.2) 15.2 (4.2) 60 HIP ENT 1.5
Geroldi et al, 2006²⁷ 52/11 MCI to D 70 (6) 44.0 27.2 (1.7) 7.2 (4.2) 15.4 MTL NA
Visser et al, 1999²⁸ 13/9 MD to AD 78.8 (4.8) 30.0 22.6 (2.0) 7.7 (2.1) 36 MTL 0.6
Korf et al, 2004²⁹ 75/37 MCI to D 62.9 (9.2) 40.0 26.9 (2.9) 10.2 (3.0) 34 MTL 1.5
Visser et al, 2002³⁰ 26/7 MCI to AD 64.9 (9.5) 58.1 27.7 (1.8) 10.7 (3.2) 22.8 HIP 1.5
Dickerson et al, 2001³¹ 23/12 MCI to AD 68.6 (8.6) 67.9 27.0 (2.2) 15.2 (3.1) 15 ENT 1.5
Teipel et al, 2007³² 22/7 aMCI to AD 69.7 (8.5) 45.8 27.0 (1.8) NA 27.0 MTL AA 1.5
Killiany et al, 2000³³ 79/19 QA to AD 72 40.0 29.1 NA 36 STS, AC NA
Note:—MRI indicates MR imaging; AA, neocortical association areas; AC, anterior cingulate; ENT, entorhinal cortex; HIP, hippocampus; Mag, magnet strength in Teslas; MD, minimal dementia; MTL, medial temporal lobe; ND, non-demented; NL, normal controls; STS, superior temporal sulcus.
* Each cell was listed as mean value (SD).
† Including 12 MCI and 2 NL.