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Table 5: Relationship between radial diffusivity (×10⁻³ mm²/s) and WMSA*
Brain Region WMSA on MRI P Values
Normal (n = 39) Focal (n = 59) Extensive (n = 13) Overall Normal vs Focal^† Normal vs Extensive^† Focal vs Extensive^†
Inferior frontal 
    Right 1.60 (0.17) 1.62 (0.17) 1.74 (0.24) 0.05^‡ .99 .04^‡ .11
    Left 1.55 (0.16) 1.58 (0.15) 1.65 (0.21) .15 .91 .17 .56
Inferior occipital 
    Right 1.49 (0.15) 1.55 (0.14) 1.56 (0.12) .10 .15 .34 .99
    Left 1.48 (0.16) 1.50 (0.20) 1.55 (0.17) .45 .99 .65 .99
Internal capsule 
    Right 0.75 (0.06) 0.75 (0.06) 0.82 (0.10) .004^‡ .99 .005^‡ .005^‡
    Left 0.79 (0.10) 0.79 (0.11) 0.83 (0.11) .41 .99 .65 .61
Superior frontal 
    Right 1.53 (0.14) 1.59 (0.15) 1.58 (0.21) .19 .21 .99 .99
    Left 1.47 (0.15) 1.52 (0.16) 1.56 (0.21) .16 .42 .27 .99
Sensorimotor 
    Right 1.28 (0.24) 1.37 (0.22) 1.56 (0.29) .001^‡ .16 .001^‡ .03^‡
    Left 1.31 (0.19) 1.36 (0.22) 1.52 (0.24) .008^‡ .68 .006^‡ .04^‡
Superior occipital 
    Right 1.52 (0.18) 1.49 (0.14) 1.65 (0.21) .007^‡ .99 .04^‡ .005^‡
    Left 1.51 (0.16) 1.50 (0.17) 1.57 (0.18) .40 .99 .84 .53
* Values are mean (SD).
† P values after Bonferroni correction.
‡ Significant P values.