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Table 1: Presence and distribution of the citrulline peak in patients with MS according to the VOI site revealed by ¹H-MR Spectroscopy
Patient No. Citrulline Peak on ¹H-MR Spectroscopy
NAWM CDL EDL
1 + – na
2 na – –
3 na – na
4 + – –
5 – na na
6 + + na
7 + + na
8 – – na
9 + – na
10 – – +
11 – – na
12 – + –
13 + – na
14 – – –
15 – – –
16 – – na
17 – na na
18 + + –
19 – – na
20 – – na
21 + + –
22 – + na
23 – – na
24 – + na
25 – – na
26 – – na
27 – – na
Note:—na indicates that MR spectroscopy could not be performed due to absence of such a VOI site; +, present; –, absent; MS, multiple sclerosis; VOI, voxel of interest; NAWM, normal-appearing white matter; CDL, chronic demyelinating lesions; EDL, enhanced demyelinating lesions.

Patient No.	Citrulline Peak on ¹H-MR Spectroscopy
Patient No.	NAWM	CDL	EDL
1	+	–	na
2	na	–	–
3	na	–	na
4	+	–	–
5	–	na	na
6	+	+	na
7	+	+	na
8	–	–	na
9	+	–	na
10	–	–	+
11	–	–	na
12	–	+	–
13	+	–	na
14	–	–	–
15	–	–	–
16	–	–	na
17	–	na	na
18	+	+	–
19	–	–	na
20	–	–	na
21	+	+	–
22	–	+	na
23	–	–	na
24	–	+	na
25	–	–	na
26	–	–	na
27	–	–	na