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Table 3: Sensitivity and specificity to predict MCI with different imaging measurements of WM and GM changes*
Modal Cortical Regions Sensitivity (%) Specificity (%) Accuracy (%) AUC
DTI indices Left temporal FA 1.00 0.60 0.80 0.83
Left temporal ADC 0.80 0.80 0.80 0.86
Cortical thickness Entorhinal 0.90 0.70 0.80 0.84
Middle temporal 1.00 0.60 0.80 0.81
Parahippocampal 0.60 1.00 0.80 0.80
Superior temporal 0.70 0.80 0.75 0.78
FA plus cortical thickness Left temporal FA plus entorhinal 0.80 0.80 0.80 0.87
Left temporal FA plus middle temporal 0.80 0.90 0.85 0.92
Left temporal FA plus parahippocampal 0.90 1.00 0.95 0.98
Left temporal FA plus superior temporal 1.00 0.60 0.80 0.90
ADC plus cortical thickness Left temporal ADC plus entorhinal 0.90 0.90 0.90 0.92
Left temporal ADC plus middle temporal 0.90 0.90 0.90 0.94
Left temporal ADC plus parahippocampal 1.00 0.60 0.80 0.87
Left temporal ADC plus superior temporal 0.90 0.90 0.90 0.92
Note:—AUC indicates area under the curve.
* The accuracy and quality of prediction are shown as increases in AUC when DTI and cortical thickness measurements are used concurrently.