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Table 1: Demographics, flow, and MR imaging characteristics of the study population
MC (n = 25) NonMC (n = 13)
Baseline Follow-up Baseline Follow-up
Demographics 
    Male/female 11/14 11/14 7/6 7/6
    Age (SD), years 42.2 (10) 49.4 (10) 36.7 (8) 43.8 (8)
Flow parameters 
    TCBF in mL/min (SD) 588 (128)^† − 750 (179) −
    Cerebrovascular reactivity in % (SD) 67 (20) − 68 (23) −
MR imaging parameters 
    WMH volume in % (SD) 5.0 (3.9)^† 7.4 (5.3)^** 0.0 0.0
    Infarct count (range) 6.2 (0–27)^† 9.9 (0–38)^** 0 0
    Microbleed count (range) 1.6 (0–35) 3.2 (0–40)^* 0 0
Note:—MC indicates mutation carriers; NonMC, nonmutation carriers; TCBF, total cerebral blood flow; WMH, white matter hyperintensities. The 2-sample ttest is used for comparisons of age, TCBF, and CVR. The Mann-Whitney U test is used for baseline comparisons of WMH volume, infarcts, and microbleeds. The χ² test is used for male/female. CVR data are based on measurements in 14 MCs and 9 nonMCs.
* Difference (P < .05) between baseline and follow-up.
** Difference (P < .01) between baseline and follow-up.
† Difference (P < .01) between MCs and nonMCs at baseline.