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Table 1: Scan-rescan group lesion volume and interscan coefficient of variation
Methods Baseline Lesion Volume, Mean ± SD, cm³ Rescan Lesion Volume, Mean ± SD, cm³ Average Interscan COV, Mean ± SD, % Lesion Volume Change, Mean ± SD, cm³ Percentage of Lesion Volume Change, Mean ± SD, %
CSEG 7.98 ± 6.8^* 8.50 ± 7.66 8.64 ± 9.91 0.77 ± 1.1 11.40 ± 12.00
SSEG 7.98 ± 6.8^* 8.12 ± 7.08^† 0.98 ± 1.55 0.14 ± 0.28 1.50 ± 2.30
Note:—COV indicates coefficient of variation; CSEG, serial single time-point conventional segmentation; SSEG, segmentation of subtraction images.
* The same baseline lesion volume (calculated with CSEG) is used with the 2 methods.
† Rescan volume with SSEG = baseline volume (calculated with CSEG) + net lesion volume change (calculated with SSEG); percentage of lesion volume change = lesion volume change/baseline lesion volume.