Tumors and nonneoplastic lesions: metabolite ratios and rCBV*

Metabolites	Low-Grade Tumors	High-Grade Tumors	All Tumors	Stroke	Demyelination	Proved Benign	Stable Lesions	All Nonneoplastic Lesions	P^†
	N = 8	N = 28	N = 36	N = 4	N = 10	N = 10	N = 9	N = 33
NAA/Cho	0.58 ± 0.31	0.34 ± 0.18	0.40 ± 0.23	0.72 ± 0.46	0.95 ± 0.39	1.08 ± 0.41	0.76 ± 0.22	0.91 ± 0.38	.0001
NAA/Cr	1.05 ± 0.51	0.78 ± 0.28	0.84 ± 0.36	1.02 ± 0.70	1.83 ± 1.01	1.06 ± 0.33	1.07 ± 0.40	1.29 ± 0.73	.002
Cho/Cr	2.10 ± 0.98	2.84 ± 2.43	2.68 ± 2.20	1.45 ± 0.55	1.88 ± 0.60	1.03 ± 0.23	1.40 ± 0.23	1.44 ± 0.52	.002
NAA_norm	0.43 ± 0.20	0.35 ± 0.15	0.37 ± 0.16	0.48 ± 0.36	0.64 ± 0.24	0.48 ± 0.17	0.53 ± 0.14	0.54 ± 0.21	.0001
Cho_norm	1.63 ± 0.44	2.10 ± 1.06	2.00 ± 0.98	1.05 ± 0.11	1.55 ± 0.56	0.75 ± 0.27	1.33 ± 0.31	1.19 ± 0.49	.0001
Cr_norm	0.94 ± 0.35	1.09 ± 0.52	1.06 ± 0.49	0.93 ± 0.25	1.02 ± 0.41	0.92 ± 0.37	1.06 ± 0.24	0.99 ± 0.33	NS
rCBV^‡	1.45 ± 1.16	4.87 ± 3.12	4.11 ± 3.14	1.30	1.31 ± 0.49	0.77 ± 0.27	1.07 ± 0.44	1.00 ± 0.39	.002

Note:—NS indicates not significant; rCBV, relative cerebral blood volume; NAA/Cho, ratio of N-acetylaspartate to choline; NAA/Cr, ratio of N-acetylaspartate to creatine; Cho/Cr, ratio of choline to creatine.
* Data are presented as means ± standard deviations.
† t test comparison of tumors and nonneoplastic lesions.
‡ MRI perfusion cases: low-grade tumors (N = 4), high-grade tumors (N = 14), stroke (N = 1), demyelination (N = 2), proved benign (N = 5), stable lesions (N = 4).