1naresh
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Total (n = 91) Reocclusion (n = 16) No Reocclusion (n = 75) P Value Mean age (years) 67 ± 15 70 ± 14 66 ± 16 .58 Male patients (No., %) 48 (53) 8 (50) 40 (53) .81 Occlusion site: .92 MCA 48 (53%) 9 (56%) 39 (52%) ICA 29 (32%) 5 (31%) 24 (32%) ACA 2 (2%) 0 (0%) 2 (3%) BA 12 (13%) 2 (13%) 10 (13%) Study protocol* .18 Group 1 47 (52%) 9 (56%) 38 (51%) Group 2 12 (13%) 4 (25%) 8 (11%) Group 3 19 (21%) 3 (19%) 16 (21%) Group 4 13 (14%) 0 (0%) 13 (17%) Mean time to treatment (h) 4.36 ± 2.18 4.05 ± 1.27 4.42 ± 2.33 .06 Initial Qureshi grade 0–3B 53 (58%) 9 (56%) 44 (59%) .86 Initial Qureshi grade 4A-5 38 (42%) 7 (44%) 31 (41%) Final recanalization† <.01 None 19 (21%) 2 (13%) 17 (23%) Partial 41 (45%) 13 (82%) 28 (37%) Complete 29 (32%) 1 (6%) 28 (37%) Symptomatic ICH (No.) 10 3 7 .46 Median initial NIHSS score 19 (±8) 19 (±7) 19 (±8) .90 Median 24-hour NIHSS score 18 ± 13 22 (±11) 17 (±13) .18 Median 7-day NIHSS score 18 ± 16 25 (±16) 17 (±16) .06 Favorable mRS‡ at 1–3 months (No., %) 29 (32) 1 (6) 28 (37) .02 Favorable 1–3 mRS at 1–3 months among treatment responders§ (n = 70) 24/70 (34%) 1/16 (6%) 23/56 (41%) .01
Note:—MCA indicates middle cerebral artery; ICA, internal carotid artery; ACA, anterior cerebral artery; BA, basilar artery; h, hour; ICH, intracerebral hemorrhage; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.
* Group 1, IA reteplase and MTD; group 2, EKOS MicroLysUS North American trial; group 3, MTD following IV thrombolysis; group 4, IA reteplase and IV abciximab (FDA IND 9180).
† Defined as ≤2.
‡ Data were missing on 2 patients.
§ Patients who never demonstrated recanalization were excluded from the analysis.