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Table 2: 
Correlation coefficients between clinical measurements and net lesion volume change and annual lesion volume change per year
MeasurementNet Lesion Volume Change, cm3Annual Lesion Volume Change, cm3/y
SSEG, R, PCSEG, R, PSSEG, R, PCSEG, R, P
Net BPF change−0.446, 0.046*−0.180, 0.421N/AN/A
Annual BPF changeN/AN/A−0.430, 0.055†−0.232, 0.299
Interval time between MR imaging scans0.234, 0.2950.151, 0.499N/AN/A
Disease durationN/AN/A−0.508, 0.023*−0.360, 0.108
  • Note:—CSEG indicates serial single time-point conventional segmentation; SSEG, segmentation of subtraction images; BPF, brain parenchymal fraction; N/A, nonapplicability of a paired correlation. SSEG reveals relationships with net BPF change and disease duration, whereas CSEG does not.
  • * Significant results.
  • † Nearly significant results.