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Table 1: VBM method protocol
VBM Action Algorithm
Step 1: preprocessing Affine register to MNI template; SPM5^*
skull strip images; BET
segment gray matter; SPM5
manifold additional affine registration air, define common air
Step 2: statistics 1) Simple t test between converters and nonconverters; SPM5
2) Model with covariates; condition: conversion or not; nuisance variables: age, sex, global gray matter; NYU; MMSE not included due to significant interaction with NYU; SPM5
3) Reporting of results at P < .1 corrected and anatomic percentages aal
Note:—BET indicates brain extraction tool; MNI, Montreal Neurologic Institute; NYU, New York University paragraph recall test; MMSE, Mini-Mental State Examination; aal, automatic anatomic labeling.
* SPM software, versions SPM2 and SPM5.

VBM	Action	Algorithm
Step 1: preprocessing	Affine register to MNI template;	SPM5^*
	skull strip images;	BET
	segment gray matter;	SPM5
	manifold additional affine registration	air, define common air
Step 2: statistics	1) Simple t test between converters and nonconverters;	SPM5
	2) Model with covariates; condition: conversion or not; nuisance variables: age, sex, global gray matter; NYU; MMSE not included due to significant interaction with NYU;	SPM5
	3) Reporting of results at P < .1 corrected and anatomic percentages	aal