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Table 3: Missense mutations of the GFAP gene in 11 patients with AOAD
Pt/Age/Sex Missense Mutations
Exon Nucleotide Change Amino Acid Substitution
1/26/M 6 c.1076T>C p.L359P^*
2/36/F 8 c.1178G>T p.S393I*
3/26/M 8 c.1246C>T^‡ p.R416W
4/39/F 1 c.209G>A p.R70Q^*
5/30/M 3 c.613G>A p.E205K^†
6/43/F 1 c.208C>T^‡ p.R70W
7/61/M 6 c.994G>A p.E332K
8/58/M 3 c.613G>A p.E205K^†
 9/52/F 8 c.1193C>A p.S398Y^†
10/64/M 1 c.382G>A p.D128N^†
11/45/M^§ − − −
Note:—GFAP indicates glial fibrillary acidic protein; AOAD, adult-onset Alexander disease.
* Mutations p.L359P,¹⁷ p.S393I,¹⁸ and p.R70Q¹⁹ have been found in these patients for the first time.
† These mutations have not been reported previously.
‡ Molecular data of patients 3 and 6 have been reported previously.¹⁹
§ Patient 11 carried no causative mutations but harbored the p.D157N rare polymorphism.