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Table 4: Correlations between biomarkers and episodic memory
RAVLT Learning^* RAVLT 30 Minutes’ Recall
R R
S1 S2 S1 S2
Hippocampus .49^§ .70^†^‡ .35 .71^†^‡
A: Middle temporal LH .51^† .38 .33 .22
B: Inferior parietal LH .67^† .44^§ .48^‡ .53^†
C: Entorhinal LH .66^† .64^†^‡ .46 .64^†^‡
D: Precuneus (toward isthmus) LH .50^† .48^† .15 .44^†
E: Superior frontal LH .43 .42 .24 .38
A: Middle temporal RH .49^§ .34 .16 .39^†
B: Inferior parietal RH .56^† .49^† .53^† .60^†
C: Entorhinal RH .35 .50^† .23 .53^†
D: Precuneus (toward isthmus) RH .28 .54^† .04 .54^†
E: Superior frontal RH .38 .36 .29 .22
Tau −.28 −.60^† −.09 −.73^†^‡
Aβ42 .09 .42 .33 .35
APOE −.09 −.17 −.34 −.18
Note:—S1 indicates Sample 1; S2, Sample 2; RAVLT, Rey Auditory-Verbal Test; APOE, apolipoprotein E; Aβ42; amyloid beta 42 peptide; LH, left hemisphere; RH, right hemisphere; R, Pearson r.
* RAVLT learning is the sum of correct responses across learning trials 1 to 5. APOE is quantified as the number of ε4 alleles (0, 1, or 2). For tau, cutoff criteria are used in the analyses (0 for nonpathologic, 1 for pathologic), whereas for Aβ42 the actual values are used because only 2 participants in Sample 1 had pathologic values.
† P < .05.
‡ P < .05 when the effect of age is controlled for.
§ P < .06.