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Table 2: Histologic evaluations of mild HI-induced WM damage in injury and control ECs from D1 to D90 post-HI*
Injury EC Control EC Ratio P
LFB staining intensity (optical density) 
    D1 0.055 ± 0.006^a 0.081 ± 0.008^a 0.684 ± 0.086^a <.01
    D7 0.098 ± 0.008^b 0.129 ± 0.017^b 0.768 ± 0.097^b <.01
    D14 0.113 ± 0.014^c 0.143 ± 0.015^b 0.801 ± 0.160^b <.01
    D30 0.143 ± 0.015^d 0.173 ± 0.012^c 0.818 ± 0.083^b <.01
    D90 0.177 ± 0.021^e 0.214 ± 0.026^d 0.824 ± 0.092^b <.01
Axon count 
    D1 201 ± 29^a 234 ± 32^a 0.859 ± 0.129 .074
    D7 463 ± 48^a 503 ± 85^a 0.920 ± 0.084 .254
    D14 679 ± 19 697 ± 32^a 0.974 ± 0.025 .087
    D30 701 ± 132 716 ± 89^a 0.979 ± 0.084 .724
    D90 1059 ± 476^b 1240 ± 402^b 0.854 ± 0.025 .335
Note:—WM indicates white matter; LFB, Luxol fast blue.
* A paired t test was used to evaluate the statistical significance between injury and control ECs. One-way analysis of variance followed by a Tukey test was used to evaluate the statistical significance among longitudinal time points. Superscript a,b,c,d,e reflect significant differences between time points. Values in the same column without a common superscript indicate a significant difference less than 0.05 between 2 time points. Values are shown as mean ± SD.