Table 2:

Correlation coefficients (r) between CC areas and ARWMC volume measured in standard space*

Areas	Mean ARWMC (mL)	Mean CC Areas vs Mean ARWMC (mL) in the Brain (r)
Areas	Mean ARWMC (mL)	CC1	CC2	CC3	CC4	CC5	CC Total
Mean CC area (mm²)		179.3 ± 40.1	93.8 ± 25.2	90.8 ± 24.0	91.5 ± 27.3	184.0 ± 39.8	642.6 ± 135.4
ARWMC
Basal ganglia region	0.7 ± 0.9	−0.111	−0.077	0.039	−0.038	−0.162^‡	−0.095
Frontal lobes	14.7 ± 15.4	−0.181^§	−0.078	0.027	−0.07	−0.232^§	−0.144^†
Occipital lobes	1.2 ± 1.6	−0.181^‡	−0.107	−0.004	−0.04	−0.223^§	−0.146^†
Parietal lobes	6.0 ± 7.4	−0.137^†	−0.097	−0.004	−0.067	−0.201^§	−0.132^†
Temporal lobes	1.3 ± 1.9	−0.154^‡	−0.157^‡	−0.067	−0.104	−0.206^§	−0.168^‡
Total ARWMC	24.0 ± 25.0	−0.175^‡	−0.076	0.035	−0.042	−0.230^§	−0.134^†

Note:—CC indicates corpus callosum; ARWMC, age-related white matter changes.
* All CC and ARWMC values were normalized to the same head size. Values are mean CC areas and mean ARWMC volume (± SD), relative volume of the ARWMC volume assessed relative to the entire anatomic region, correlation coefficients (r), and significance level. In addition to the log-transformed ARWMC per brain region, we entered the following covariates: number of lacunes per brain region, number of infarcts, age, handedness, recruiting center, and ratings of sulcal and ventricular atrophy.
† P < .01.
‡ P < .001.
§ P < .0001 (uncorrected).