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Table 2: 
Estimated means and 95% CIs of BBBP measurements according to the Patlak model and the parameters describing the quality of the linear regression*
First-PassDelayed PhaseP Value
Ischemic ROIs (N = 290)
    BBBP (95% CI)7.63 (4.78–12.19)1.31 (1.03–1.68)<.001
    √MSE × 103 (95% CI)0.59 (0.36–0.96)0.089 (0.073–0.11)<.001
    R (95% CI)0.53 (0.46–0.61)0.69 (0.59–0.78)<.001
Nonischemic ROIs (N = 1560)
    BBBP (95% CI)2.81 (2.42–3.27)1.05 (0.97–1.14)<.001
    √MSE × 103 (95% CI)0.18 (0.14–0.24)0.041 (0.035–0.048)<.001
    R(95% CI)0.57 (0.52–0.61)0.85 (0.81–0.88)<.001
  • Note:—ROI = regions of interest; BBBP, blood-brain barrier permeability; √MSE, squareroot mean squared errors.
  • * A √MSE close to 0 indicates a smaller spread of data points around the line, corresponding to a better fit. An R close to 1 indicates a stronger linearity.