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Table 1: 
Demographic, clinical, and MR imaging—based measured brain characteristics of patients with MS used in the cross-sectional analysis*
PPMSSPMSRRMS
No. (female-male)20 (9:11)14 (12:2)30 (25:5)
Mean age ± SD (yr)52.5 ± 8.853.2 ± 11.739.8 ± 9.5
Mean disease duration ± SD (yr)9.1 ± 5.3416.9 ± 8.37.3 ± 6.6
EDSS (mean, median, range)5.0, 6, 2–7.55.5, 6, 2–7.51.4, 1, 0–5
AI (mean, median, range)3.2, 2, 0–83.4, 2.5, 1–80.54, 0, 0–2
BPF (mean ± SD)0.84 ± 0.050.80 ± 0.050.87 ± 0.04
MOV (cm3, mean ± SD)0.84 ± 0.120.78 ± 0.111.06 ± 0.18
Total CC area (cm2, mean ± SD)566.3 ± 81.6469.8 ± 89.0566.1 ± 85.3
CC-segment 1214.1 ± 30.2189.9 ± 40.0223.0 ± 39.0
CC-segment 266.2 ± 12.656.9 ± 9.267.0 ± 14.1
CC-segment 362.9 ± 10.849.3 ± 5.561.1 ± 13.2
CC-segment 451.5 ± 13.338.4 ± 9.248.8 ± 13.2
CC-segment 5171.6 ± 32.1135.4 ± 35.8166.1 ± 29.2
  • Note:—PPMS indicates primary-progressive multiple sclerosis; SPMS, secondary-progressive multiple sclerosis; RRMS, relapsing-remitting multiple sclerosis; SD, standard deviation; EDSS, expanded disability status scale; AI, ambulation index; BPF, brain parenchymal fraction; CC, corpus callosum; MOV, medulla oblongata volume.
  • * The corpus collasum and MOV measurements are normalized as described in the “Materials and Methods” section.