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Table 1: 
Age-related white matter change scale*
LocationCharacteristics†
White matter
    0No lesions (including caps/bands)
    1Focal lesions
    2Beginning confluence of lesions
    3Diffuse involvement of the entire region, irrespective of U fiber involvement
Basal ganglia
    0No lesions
    11 focal lesion (≥5 mm)
    2>1 focal lesion
    3Confluent lesions
  • * Brain regions assessed included frontal, parieto-occipital, temporal, infratentorial/cerebellum, and basal ganglia (striatum, globus pallidus, thalamus, internal/external capsule, and insula).
  • † White matter changes on MR imaging are defined as bright lesions ≥5 mm on T2, proton-density, or fluid-attenuated inversion recovery images. Lesions on CT were defined as hypodense areas of ≥5 mm; left and right hemispheres were rated separately.