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Table 5: CTP variables predictive of WM disease after adjusting for age confounder, as obtained by the univariate logistic regression analysis (n = 35)
CTP Variables Age Confounder
P Value OR (95% CI) P Value OR (95% CI)
CBF 
Periventricular WM .05^† 0.727 (0.529–0.999) .195^† 1.062 (0.970–1.163)
Subcortical WM .03^† 0.635 (0.419–0.963) .069^† 1.094 (0.993–1.205)
Average WM .03^† 0.644 (0.457–0.964) .145^† 1.069 (0.977–1.171)
Average GM .20 0.916 (0.802–1.047) .099 1.083 (0.985–1.190)
CBV 
Periventricular WM .03^‡ 0.992 (0.986–0.999) .043^‡ 1.112 (1.003–1.233)
Subcortical WM .06 0.995 (0.989–1.000) .023 1.132 (1.017–1.259)
Average WM .03^‡ 0.993 (0.986–0.999) .027^‡ 1.128 (1.014–1.256)
Average GM .20 0.998 (0.995–1.001) .035 1.101 (1.007–1.205)
MTT 
Periventricular WM .86^‡ 0.938 (0.470–1.870) .048^‡ 1.103 (1.001–1.216)
Subcortical WM .24 1.335 (0.826–2.158) .043 1.095 (1.003–1.196)
Average WM .99^‡ 0.995 (0.442–2.242) .040^‡ 1.120 (1.005–1.248)
Average GM .97 1.011 (0.553–1.848) .035 1.100 (1.005–1.203)
Note:—CI indicates confidence interval; WM, white matter; GM, gray matter; CBV, cerebral blood volume; MTT, mean transit time; CBF, cerebral blood flow; CTP, CT perfusion.
† CTP variable is significant (P < .05) when the age confounder is not related to the disease.
‡ CTP variable is significant (P < .05) when the age confounder is related to the disease.