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Table 2: 

Association of genotypes of the SNPs significant in LPM analyses with total T2 lesion volume in the brain
Geners No.Mean Whole Brain T2 Lesion Volumes in mL (SD)P Value of Differences in Total Lesion Volume
Genotype of InterestaOther GenotypesBetween Genotypes (Mann-Whitney U test)Corrected for Disease Duration (using GLM)
Increased local volume in LPM analyses
    BTNL2rs2076530bAG 32.0 (32.9)AA and GG 23.8 (27.4)0.04c0.05c
    CCL5rs2107538CC 28.2 (29.0)CT and TTd 20.9 (28.1)0.02c0.07
    IFNGR2rs9808753AA 28.5 (30.5)AG and GGd 18.3 (22.6)0.04c0.29
    PNMTrs876493AG 28.1 (29.0)AA and GG 23.2 (28.6)0.150.13
    HLArs2227139CT 28.0 (29.9)CC and TT 23.9 (28.0)0.350.25
Decreased local lesion probability in LPM analyses
    BTNL2rs2076530cGG 18.7 (22.7)AA and AG 26.6 (29.5)0.130.04c
    CRYABrs762550AA 19.8 (21.0)AG and GG 27.0 (30.2)0.280.30
    FASrs2234978TT 12.5 (14.7)CC and CT 27.1 (29.7)0.02c0.06
    FASrs3781202CT 23.1 (28.5)CC and TT 28.4 (29.1)0.180.37
    NDUFS7rs2074897GG 18.4 (23.7)AA and AG 28.2 (30.1)<.01c0.08
    UCP2rs659366CC 18.6 (23.1)CT and TT 29.8 (31.1)<.01c<.01c
  • 


    a Genotypes that are significantly associated with altered local lesion probability in LPM analyses.
  • 


    b Different genotypes of this same SNP are involved in decreased and increased lesion probability.
  • 


    c P values of significant associations to total T2 lesion volume.
  • 


    d Because of the frequency of <5% of homozygote genotype, these genotypes (TT for CCL5 and GG for IFNGR2) were only analyzed when combined with heterozygote genotypes.